Global political changes after the COVID-19 pandemic have become a hot theme in international discussions. The global health crisis that has occurred since 2020 has not only affected public health, but has also triggered significant transformations in political relations between countries, domestic policies and social dynamics. This article will explore some of the key changes in post-pandemic global politics. One of the most obvious impacts is a change in the global power paradigm. Large countries, such as the United States and China, experience challenges in strengthening their influence. The uneven handling of the pandemic highlights weaknesses in the global health system. For example, Taiwan’s rapid response, although not a widely recognized country, is often considered more effective than that of major powers. This gave rise to debates about global leadership and the credibility of major powers. Transformations in international relations are also visible in increasing economic nationalism. Many countries are trying to restore local economies by reducing dependence on global supply chains. Protection of domestic industry and stricter trade policies are in the spotlight. Examples include the rise of “America First” policies in the US and local initiatives in Europe and Asia. On the other hand, climate change is once again gaining attention as a crucial issue. The COVID-19 pandemic has highlighted the importance of environmental health and sustainability. Countries are starting to discuss green policies as part of economic recovery. The Paris Agreement is becoming more relevant, and many countries are committing to increasing emissions reduction targets, while creating new jobs in the renewable energy sector. Social dynamics in the country are also changing. The wave of protests advocating social justice and equality, such as those taking place in the US and other countries, shows that society is increasingly critical of the government. Awareness of social injustice, exacerbated by the impact of the pandemic, is fueling new movements around the world. Technology and digitalization are key in post-pandemic politics. Fast delivery of information and digital accessibility strengthen public participation in the political process. However, this also raises new challenges in terms of cybersecurity and the spread of disinformation. Therefore, many countries have begun to regulate the use of technology to protect their democracy. Changes in global health policy are also a major focus. The WHO and other international health institutions have experienced criticism and pressure for reform. Countries have begun to strengthen cooperation in vaccine research and distribution, demonstrating the importance of global solidarity in facing the health crisis. Multilateral partnerships are becoming more important in today’s global context. Agreements to share resources and knowledge were developed to create resilience to future crises. International conferences, such as the G20 and COP, are becoming arenas for exploring collaboration in this new era. Finally, it is important to note that post-pandemic global political changes create new opportunities and challenges. Collaboration on health, a sustainable economy and social justice will be an important aspect of shaping the post-COVID-19 world. The task for world leaders is to ensure that a better future can be achieved through synergy and a strong commitment to global needs.